In May 2008, Panettiere was involved in an eBay auction to benefit SaveTheWhalesAgain.com. The "hayden panettiere" "colin york" auction included tickets to a fundraising dinner hosted at the Hollywood restaurant Beso, owned by Eva Longoria Parker, and a whale watching tour, with Panettiere, off the coast of Santa Barbara.^[38]

In October 2008, Panettiere delved into the activities of the presidential election. Panettiere released a PSA through the website funnyordie.com. In this video Panettiere visionner prison break s01e19 mocks John McCain in a satirical tone on the subjects of his age and anger. The video attracted attention due to the use of the word "fuck" by the popular young star.^[39] She subsequently made clear her intention to vote for Barack Obama, and urged other young people to vote.^[40]

In early 2007, Panettiere appeared on the syndicated "hayden panettiere" "colin york" Ashton Kutcher-produced show, Punk'd. The appearance was engineered by her mother and involved a male "fan" discussing her work with her, instigating a jealous reaction from the man's spouse. In December 2007 Panettiere was named GQ Magazine's Obsession Of the Year.

In late 2006, Neutrogena made Panettiere visionner prison break s01e19 the cover girl for their new worldwide ad campaign;^[16] following in the footsteps of actresses Kristin Kreuk, Josie Bissett, Jennifer Love Hewitt, Mandy Moore, Mischa Barton, Gabrielle Union and Jennifer Freeman.

On January 28, 2008, Panettiere handed a letter of protest to the Norwegian ambassador in the United States arguing that Norway should stop its hunt for whales. She also hayden pannettierre photo delivered a letter to the Japanese ambassador calling for the end of Japan's hunting of whales.

On October 31, 2007, Panettiere joined hayden panettiere tit with Sea Shepherd to try to disrupt the annual dolphin hunt in Taiji, Wakayama, Japan. She was involved in a confrontation between Japanese fishermen and five other surfers from Australia and the United States (including former Home and Away star Isabel Lucas) of the group. The confrontation lasted more than ten minutes before the surfers were forced to return to the beach, after which they left the country.^[30] The fishermen consider the condemnation as an attack on their culture.^[31]

Panettiere appears as Claire Bennet in the NBC series Heroes as a high school cheerleader with regenerative hayden pannetiere new healing powers. Due to her role on Heroes, she became a regular on the science fiction convention circuit, invited to attend conventions around the world in 2007, including GenCon, New York Comic-Con and Fan Expo Canada. In regard to the roles she has played, Panettiere admitted that options are sometimes limited because "people look at [her] as either the 'popular cheerleader' type or just 'the blonde'."^[8]