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In late 2006, Neutrogena stiletto heels made Panettiere the cover girl for their new worldwide ad campaign;^[14] following in the footsteps of actresses Kristin Kreuk, Josie Bissett, Jennifer Love Hewitt, Mandy Moore, Mischa Barton, Gabrielle Union and Jennifer Freeman.

On January 28, 2008, Panettiere handed a letter of protest to the Norwegian ambassador in the United States arguing that Norway should stop its hunt for whales. She also delivered a letter punk'd hayden panettiere en francais to the Japanese ambassador calling for the end of Japan's hunting of whales.

On October 31, 2007, Panettiere participated in the activity of Sea Shepherd to try to disrupt the annual dolphin hunt in Taiji, Wakayama, Japan. She was involved in a confrontation between Japanese fishermen and five other surfers from Australia and the United States (including former Home and Away star Isabel Lucas) of the group. The confrontation lasted more than ten minutes before the surfers were forced to return to the beach, after TECKTONIC 50min inside which they left the country.^[28] The fishermen consider the condemnation as an attack on their culture.^[29]