In May 2008, Panettiere was involved in an eBay auction to benefit SaveTheWhalesAgain.com. The "hayden panettiere" "colin york" auction included tickets to a fundraising dinner hosted at the Hollywood restaurant Beso, owned by Eva Longoria Parker, and a whale watching tour, with Panettiere, off the coast of Santa Barbara.^[38]

In October 2008, Panettiere delved into the activities of the presidential election. Panettiere released a PSA through the website funnyordie.com. In this video Panettiere hayden pannetiere new mocks John McCain in a satirical tone on the subjects of his age and anger. The video attracted attention due to the use of the word "fuck" by the popular young star.^[39] She subsequently made clear her intention to vote for Barack Obama, and urged other young people to vote.^[40]

In February 2008, Kohl's announced that Panettiere would be their next Candie's spokesperson. She will be following the likes of Fergie, Hilary Duff, and Kelly Clarkson.^[18]

In October, Hayden debuted another satirical PSA video on funnyordie.com entitled "Vote for McCain: He's just like George Bush, except older and with a worse temper".^[13].

In September 2007, Panettiere appeared in a Heroes-themed Got Milk? ad photographed by Annie Leibovitz.^{hayden pannettierre photo class="reference">[17]}

In September 2008, Panettiere appeared in a hayden panettiere tit PSA satire video on funnyordie.com entitled "Hayden Panettiere PSA: Your Vote, Your Choice".^[12]

In early 2007, Panettiere appeared on the visionner prison break s01e19 syndicated Ashton Kutcher-produced show, Punk'd. The appearance was engineered by her mother and involved a male "fan" discussing her work with her, instigating a jealous reaction from the man's spouse. In December 2007 Panettiere was named GQ Magazine's Obsession Of the Year.